Publication Sub Type
Journal Article, Original
International Journal of Pharmaceutical and Phytopharmacological Research
Various plants in the Philippines are currently being used to increase platelet counts in thrombocytopenic disorders including dengue hemorrhagic fever but the efficacy of such claims is uncertain. The present study investigated the platelet augmentation activity of Carica papaya L. (Family- Caricaceae), Ipomea batatas (L.) Lam (Family-Convolvulaceae), Althernanthera sessilis (L.) R. Brown ex De Candolle (Family-Amaranthaceae), Euphorbia hirta (L.) (Family-Euphorbiaceae) and Momordica charantia L. (Family-Cucurbitaceae) as potential therapy for thrombocytopenia. Plant extracts were screened for phytochemical constituents. Platelet reduction on Sprague-Dawley rats was induced by oral administration of 0.083 mg/kg body weight of anagrelide. A solution of the lyophilized aqueous plant samples were administered for 9 days. Pre-and post-treatment blood
samples for platelet counts were taken on the tenth day. Results showed that all the plant extracts tested were positive for glycosides. Extracts from Carica papaya (p=0.0002), Ipomea batatas violet variety (p=0.0070) and green variety (p=0.0000), Alternanthera sessilis (p=0.0001) and Euphorbia hirta (p=0.0489) have significant platelet augmentation (p<0.05) activity. Only Momordica charantia extract failed to show significant platelet increasing activity (p=0.1014). The percentage increase of mean platelet counts after reduction with anagrelide were as follows: Carica papaya group (125.87%), Ipomea batatas green variety group (107.88%), Ipomea batatas violet variety group (106.07%), Althernanthera sessilis group (93.17%) and Euphorbia hirta group (80.92%). These results suggest that extracts from Carica papaya, and Ipomea batatas green and violet
variety, Althernanthera sessil
1. Anti-thrombocytopenic effect of the ethanolic leaf extract of Psidium guajava linn. (guava) on Mus musculus (male albino mice).